Opiate peptides, analgesia, and the neuroendocrine system.
ثبت نشده
چکیده
منابع مشابه
Physiologically Based Pharmacokinetic (PBPK) model for biodistribution of radiolabeled peptides in patients with neuroendocrine tumours
Objective(s): The objectives of this work was to assess the benefits of the application of Physiologically Based Pharmacokinetic (PBPK) models in patients with different neuroendocrine tumours (NET) who were treatedwith Lu-177 DOTATATE. The model utilises clinical data on biodistribution of radiolabeled peptides (RLPs) obtained by whole body scintigraphy (WBS) of the patients.Methods: The blood...
متن کاملEndogenous opiate peptides, stress reactivity, and risk for hypertension.
Endogenous opiate peptides can regulate neuroendocrine and circulatory responses to behavioral stress and may be important in the pathogenic effects of sympathoadrenal reactivity. We tested this hypothesis by examining the effect of the opiate antagonist naloxone on blood pressure responses to behavioral stress in young adults with high, medium, or low casual blood pressures. Naloxone increased...
متن کاملOpioid peptides and opiate alkaloids in immunoregulatory processes
Among the various non-neuronal cell types known to express and utilize neuropeptides, those of the immune system have received much attention in recent years. In particular, comparative studies in vertebrates and invertebrates have shown that endogenous opioid peptides are engaged in receptor mediated autoregulatory immune and neuroendocrine processes. The majority of these immune processes are...
متن کاملNonopiate active proenkephalin-derived peptides are secreted by T helper cells.
Recent investigations have shown that the neuroendocrine and immune systems profoundly affect each other. In part, these interactions occur via common chemical messengers and receptors. One possible shared chemical messenger is the opioid precursor preproenkephalin, for which high concentrations of messenger RNA are present in brain, adrenal, and activated T helper cells. Because the biologic a...
متن کاملEnkephalins and endorphins: the endogenous opiates.
The discovery of the opiate receptors in the central nervous system of man and subsequent identification of endogenous opiate-like ligands (enkephalins and endorphins) has provided a model for the analgesia, euphoria and addiction produced by the narcotics. In this article, the author reviews the background, biosynthesis and degradation, distribution, nociceptive transmission and analgesic effe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British medical journal
دوره 280 6216 شماره
صفحات -
تاریخ انتشار 1980